Further Clinical and Laboratory Experiences with Coly-Mycin (Colistin)

Stability of colistin methanesulfonate in pharmaceutical products and solutions for administration to patients.

Colistin methanesulfonate (CMS) has the potential to hydrolyze in aqueous solution to liberate colistin, its microbiologically active and more toxic parent compound. While conversion of CMS to colistin in vivo is important for bactericidal activity, liberation of colistin during storage and/or use of pharmaceutical formulations may potentiate the toxicity of CMS. To date, there has been no info...

Further experiences with methylated thiobarbiturates.

FIG. 1 Formulae of the drug under study. Limited supplies of two further methylated thiobarbiturates, described by Peel et al. (1959), known as B.82 and B.133 have become available. The formulae of these are shown in figure 1 and it can be seen that B.82 is the methylated form of buthalitone. B.133 is not related chemically to any thiobarbiturate in clinical use, being sodium N-methyl 5-ethyl 5...

Exotica: A Further Miscellany of Clinical and Pathological Experiences

Further experiences with fentanyl and droperidol.

INXTmL ~a'm~ENCm with fentanyl and dihydrobenzperidol containing 25 per cent of an analogue benzperidol indicated that a combination of these drugs could be of value during induction or maintenance of general anaesthesia. 1 Of particular interest was the frequency with which patients recovered consciousness while remaining in an analgesic state which persisted for some time, thus permitting ful...

Further experiences with segmental resection in tuberculosis.